Table 9.

MR results of the causal effect of ER-negative BC on MMP-10.

Exposure	Outcome	No. of SNPs	Method	β	P value	Heterogeneity		Pleiotropy
						Cochrane's Q	P	P
ER-negative BC (ieu-a-1128)	MMP10	37	MR Egger	− 0.13	0.08	46.00	0.10	0.08
			Weighted median	0.007	0.83
			Inverse variance weighted	− 0.009	0.74	50.38	0.06
			Simple mode	0.05	0.45
			Weighted mode	0.01	0.80
ER-negative BC (ieu-a-1135)	MMP10	14	MR Egger	0.04	0.66	13.77	0.32	0.62
			Weighted median	− 0.007	0.87
			Inverse variance weighted	− 0.002	0.94	14.07	0.37
			Simple mode	− 0.02	0.69
			Weighted mode	− 0.02	0.75
ER-negative BC (ieu-a-1136)	MMP10	7	MR Egger	− 0.32	0.12	6.67	0.25	0.13
			Weighted median	0.02	0.75
			Inverse variance weighted	− 0.02	0.71	11.11	0.08
			Simple mode	0.02	0.86
			Weighted mode	0.03	0.76
ER-negative BC (ieu-a-1166)	MMP10	8	MR Egger	− 0.44	0.15	7.75	0.26	0.13
			Weighted median	0.01	0.78
			Inverse variance weighted	0.02	0.59	11.81	0.11
			Simple mode	0.003	0.97
			Weighted mode	0.004	0.96

BC Breast cancer; ER Estrogen receptor; MMP Matrix metalloproteinases; MR Mendelian randomization; SNP Single nucleotide polymorphisms.