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. 2023 May 15;14:2771. doi: 10.1038/s41467-023-38475-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a–c A tremor in freely moving mice. Control: N = 10 (5 female/5 male); Atoh1^Cre/+;Vglut2^fl/fl: N = 13 (6 f/7 m). a Power spectrum of tremor in control and Atoh1^Cre/+;Vglut2^fl/fl conditional knockout mice. b Mean tremor power between 0 and 30 Hz was lower in Atoh1^Cre/+;Vglut2^fl/fl mice compared to control mice (p = 0.039; d = 0.90). c Maximum tremor power was not different between Atoh1^Cre/+;Vglut2^fl/fl conditional knockouts and control mice (p = 0.276; d = 0.63). d–g Ambulatory activity in the open field assay. Control: N = 11 (6 f/5 m); Atoh1^Cre/+;Vglut2^fl/fl: N = 13 (6 f/7 m). Atoh1^Cre/+;Vglut2^fl/fl mice had lower (in d) total movement time (p = 0.03; d = 0.86), f horizontal activity count (p = 0.008; d = 1.03), and g vertical activity count (p = 0.004; d = 1.11) compared to control mice, but no difference in (e) total distance traveled (p = 0.116; d = 0.65). h Rotarod performance. Control: N = 10 (6 f/4 m); Atoh1^Cre/+;Vglut2^fl/fl: N = 13 (6 f/7 m). Atoh1^Cre/+;Vglut2^fl/fl mice fell off the rotarod faster than control mice (p = 0.017), but the group difference was only significant on the first day (p = 0.016; d = 0.83) and third training day (p = 0.025; d = 0.73), but not the second training day (p = 0.062; d = 0.58). i Three-chamber socialization assay. Control: N = 11 (6 f/5 m); Atoh1^Cre/+;Vglut2^fl/fl: N = 13 (6 f/7 m). There was no difference between Atoh1^Cre/+;Vglut2^fl/fl mice and control mice in the total time spent with a mouse (p = 0.404; d = 0.08) or an object (p = 0.948; d = 0.13), and both groups spent more time with the mouse than the object (control: p < 0.001; Atoh1^Cre/+;Vglut2^fl/fl: p < 0.001 in a two-sided paired t-test). A two-sided unpaired t-test was used to test for statistical significance unless otherwise noted. Black circles and squares represent data points from control mice; reddish purple circles and squares represent data points from Atoh1^Cre/+;Vglut2^fl/fl mice. Squares represent data points from male mice, circles represent data points from female mice. Source data and detailed statistical results are available and provided as a Source Data file.