Table 1.
Placental genes with TWAS-significant (Bonferroni-corrected p value < 0.05) association with schizophrenia and other disorders ant traits
| GWAS sample size (cases; controls) | GWAS loci | TWAS genes (g) | TWAS transcripts (tx) | TWAS unique genes (g&tx) | Reference (PMID) | |
|---|---|---|---|---|---|---|
| ADHD | 55,374 (20,183; 35,191) | 12 | 2 | 10 | 10 | Demontis, Nat.Gen 2019 (30478444) |
| Autism | 46,350 (18,381; 27,969) | 5 | 2 | 0 | 2 | Grove, Nat.Gen. 2019 (30804558) |
| Schizophrenia | 130,644 (53,386; 77,258) | 222 | 100 | 235 | 262 | Trubetskoy, Nature 2022 (35396580) |
| Bipolar Disorder | 413466 (41,917; 371,549) | 64 | 22 | 72 | 75 | Mullins, Nat.Gen. 2021 (34002096) |
| Major Depression | 173,005 (59,851; 113,154) | 43 | 23 | 28 | 37 | Wray, Nat.Gen. 2018 (29700475) |
| Intelligence Quotient | 78,308 | 336 | 7 | 8 | 14 | Sniekers, Nat.Gen.2017 (28530673) |
| Insomnia | 113,006 | 3 | 0 | 0 | 0 | Hammerschlag, Nat.Gen. 2017 (28604731) |
| Birthweight | 321,223 | 145 | 90 | 180 | 204 | Warrington, Nat.Gen. 2019 (31043758) |
| BMI | ~700,000 | 940 | 22 | 35 | 52 | Yengo, HMG 2018 (30124842) |
| Height | ~700,000 | 3,289 | 93 | 169 | 197 | Yengo, HMG 2018 (30124842) |
| Type 2 Diabetes | 659,318 (62,892; 596,426) | 142 | 48 | 103 | 117 | Xue, Nat.Comm. 2018 (30054458) |
Column 2 shows the sample size of GWAS studies (disorders and traits in column 1) that provided the summary statistics for TWAS. Column 3 shows the number of GWAS loci significantly (p value < 5e-08) associated with each disorder or trait. Columns 4, 5 report the number of genes (column 4), transcripts (column 5) with TWAS-significant association with each disorder or trait. Column 6 reports the number of unique genes with TWAS-significant association with each disorder or trait, at gene and/or transcript level. Columns 7 report the article providing the reference of the GWAS summary statistics for the TWAS.