Table 1.
Tissues | CSCs markers | Resident normal stem cells markers | References | hESC markers (33) |
---|---|---|---|---|
Breast | ALDH1, CD29, CD44, CD133, CD201, EpCAM, PODXL1, SSEA3, SSEA4, TRA-1–60, TRA-1–81, Tspan8 | Axin2, CD10, CD1d, CD24, CD29, CD49f, CD49b, CD61, CD90, CD133, CK5, CK8, CK14, CK18, CK19, c-Kit, Lrp5, Lgr5, Lgr6, EpCAM, Procr, sca1, Myh11 | (33–37) |
ABCG2, CD133, CD90, CD326, CD24, CD49f, CD146, CD10, CD117, CD26, CD29, CD9, CD166, Cripto1, Notch2, PODXL1, SSEA1, SSEA3, SSEA4, TRA-1–60, TRA-1–81 |
Prostate | ABCG2, ALDH1, CD29, CD44, CD49f, CD133, CD151, CD166, Sca1, TRA-1–60 | CD29, CD49f, CD133, Sca1, Trop2, Lgr5 | (38–42) | |
Lung | ABCG2, ALDH1, CD44, CD56, CD133, CD166, Cripto1, Notch2, Notch3, PODXL1, SSEA1, Sox2 | ABCA3, ASCL1, α-SMA, CD49f, CD271, CXCR4, GRP, KRT5, KRT8, KRT17, KRT19, LAMP3, NCAD, PDPN, ROBO, SCGB1A1, SCGB3A2, SFTPC, SMMHC, TP63, TM4SF1 | (33, 43–45) | |
Colorectal | ALDH1, CD26, CD29, CD44, CD133, CD166, Cripto1, EpCAM, Lgr5 | Lgr5 | (33, 46–49) | |
Melanoma of skin | ABCB5, ALDH1, CD20, CD133, CD271, Nanog, Oct3, Oct4 | CD29, CD46, CD49f, CD71, DLL1, DSG3, FRMD4A, LRIG1, MCSP | (50–56) | |
Renal | ALDH1, CD24, CD44, CD105, CD133, CXCR4, SSEA1 | CD13, CD29, CD44, CD73, CD90, CD105, CD133, CD146, CD224, CK7, c-kit, NR3C2, Pax2, Pax8, SSEA4 | (57–62) | |
Leukemia | ALDH1, CD9, CD25, CD26, CD32, CD33, CD34, CD44, CD47, CD93, CD96, CD97, CD99, CD103, CD123, CLL1, IL1RAP, PODXL1, TIM3 | ABCG2, CD133, CD26, CD34, CD44, CD45RA, CD49f, CD90, c-Kit, PODXL1, Sca1 | (33, 63–70) | |
Pancreas | ABCG2, ALDH1, CD133, CD9, CD24, CD44, CD49f, c-Met, CXCR1,2, CXCR4, EpCAM, GLRX3, Notch2, Nestin, Notch3, Oct3,4, PODXL1, Tspan8 | Unsure markers: Cytokeratins, PDX1, Glb1 | (33,71–78) |