Table 1.

ASO sequences and chemical modifications

Name	Sequence	Theoretical Tm (°C)
Repeat blocking	C∗A∗G∗C∗A∗G∗C∗A∗G∗C∗A∗G∗C∗A∗G	68.0
Repeat gapmer	C∗A∗G∗C∗A∗G∗C∗A∗G∗C∗A∗G∗C∗A∗G∗C∗A∗G	65.6
DMPK blocking	G∗A∗G∗C∗G∗G∗U∗U∗G∗U∗G∗A∗A∗C∗U∗G∗G	66.6
DMPK gapmer	C∗G∗G∗A∗G∗C∗G∗G∗T∗T∗G∗T∗G∗A∗A∗C∗U∗G∗G∗C	64.9
Control blocking	G∗A∗C∗G∗A∗C∗G∗A∗C∗G∗A∗C∗G∗A∗C	63.7
Control gapmer	G∗A∗C∗G∗A∗C∗G∗A∗C∗G∗A∗C∗G∗A∗C∗G∗A∗C	53.4

Bold underline, 2′-O-Me; non-bold non-underline, DNA; ∗, phosphorothioate linkage.