Figure 2.

Glucose homeostasis following HFD in global PICK1-deficient mice. The OGTT was carried out in mice at age 32 weeks following 18 weeks on chow or HFD. The effect of HFD compared with chow on glucose levels with AUC of glucose excursions for the OGTT is shown for WT (A) and (B) global PICK1-deficient mice. (C) AUC from (A) and (B). Data are shown as dot plot with mean ± SEM (n ≥ 8). Statistical significance was determined using 2-way ANOVA with Sidak's multiple comparisons test or with unpaired t-test. *P < .05, **P < .01.