Figure 3.

Global PICK1-deficient mice resist further deterioration of their glucose tolerance following STZ administration. (A) WT mice and (B) PICK1-deficient mice were injected intraperitoneally with STZ for 5 consecutive days with 35 mg per kg BW and mice were fasted once a week to measure glucose levels (n ≥ 8). (C) The OGTT was carried out in fasted vehicle-treated PICK1-deficient and WT mice, while (D) the OGTT was carried out in fasted STZ-administered PICK1-deficient and WT mice. (E) AUC of glucose excursions from (C) and (D). (F) BW was determined on a weekly basis after STZ administration for 25 weeks. Data are shown with mean ± SEM. Statistical significance was determined using 2-way ANOVA with Sidak's multiple comparisons test. *P < .05, **P < .01, ***P < .001.