Table 3. Comparison of EDSS, FAC, Barthel ADL Index, FSS, BDI, NHP subscales and total.
| MS patients with pain (n=62) | MS patients without pain (n=38) | p value | MS patients with neuropathic pain (PDQ-positive (n=18) | MS patients without neuropathic pain (PDQ-negative) (n=44) | p value | |
| EDSS | 0.452a | 0.514a | ||||
| Mean±SD | 1.42±1.92 | 1.00±1.40 | 1.44±2.43 | 1.42±1.70 | ||
| Median | 0 | 0 | 0 | 1 | ||
| Min-Max | 0-9.0 | 0-5.0 | 0-9 | 0-7.5 | ||
| FAC | 0.802a | 0.910a | ||||
| Mean±SD | 4.85±0.65 | 4.81±0.83 | 4.82±0.72 | 4.86±0.63 | ||
| Median | 5.0 | 5.00 | 5.00 | 5.00 | ||
| Min-Max | 0.00-5.00 | 0.00-5.00 | 2.00-5.00 | 100-5.00 | ||
| Barthel ADL Index | 0.306a | 0.499a | ||||
| Mean±SD | 95.32±16.06 | 97.50±12.23 | 91.66±25.72 | 96.81±9.82 | ||
| Median | 100.00 | 100.00 | 100 | 100 | ||
| Min-Max | 0.00-100.00 | 25.00-100.00 | 0.00-100.00 | 40.00-100.00 | ||
| FSS | <0.001a | 0.002a | ||||
| Mean±SD | 4.31±2.17 | 1.98±1.87 | 5.67±1.25 | 3.75±2.24 | ||
| Median | 4.82 | 1.94 | 6.05 | 4.05 | ||
| Min-Max | 0.00-7.00 | 0.00-6.77 | 2.88-7.00 | 0.00-7.00 | ||
| BDI | <0.001a | 0.115a | ||||
| Mean±SD | 17.29±10.02 | 8.07±9.45 | 20.72±10.32 | 15.88±9.66 | ||
| Median | 15.00 | 4.50 | 18.00 | 14.00 | ||
| Min-Max | 1.00-47.00 | 0.00-40.00 | 10.00-47.00 | 1.00-43.00 | ||
| NHP pain | 0.012a | |||||
| Mean±SD | 41.29±28.14 | 0 | 57.36±33.68 | 34.72±22.87 | ||
| Median | 34.71 | 0 | 56.74 | 26.01 | ||
| Min-Max | 5.83-100.00 | 0-0 | 0.00-100.00 | 0.00-100.00 | ||
| NHP emotional reaction | <0.001a | 0.140a | ||||
| Mean±SD | 40.59±29.63 | 16.37±20.83 | 48.06±26.18 | 37.53±30.69 | ||
| Median | 38.38 | 11.24 | 51.99 | 33.75 | ||
| Min-Max | 0.00-100.00 | 0.00-100.00 | 7.08-86.01 | 0.00-100.00 | ||
| NHP sleep | 0.007a | 0.083a | ||||
| Mean±SD | 28.23±28.71 | 14.50±24.75 | 38.77±30.29 | 23.92±27.22 | ||
| Median | 16.10 | 0.00 | 43.71 | 16.10 | ||
| Min-Max | 0.00-100.00 | 0.00-100.00 | 0.00-77.63 | 0.00-100.00 | ||
| NHP social isolation | 0.004a | 0.242a | ||||
| Mean±SD | 31.37±33.18 | 13.42±24.72 | 38.76±34.91 | 28.35±32.36 | ||
| Median | 22.01 | 0.00 | 29.05 | 21.07 | ||
| Min-Max | 0.00-100.00 | 0.00-100.00 | 0.00-100.00 | 0.00-100.00 | ||
| NHP physical abilities | <0.001a | 0.247a | ||||
| Mean±SD | 29.36±23.61 | 12.40±14.98 | 34.23±25.10 | 27.37±22.97 | ||
| Median | 22.74 | 11.20 | 32.41 | 22.16 | ||
| Min-Max | 0.00-100.00 | 0.00-67.16 | 0.00-100.00 | 0.00-100.00 | ||
| NHP energy level | <0.001a | 0.154a | ||||
| Mean±SD | 71.23±35.46 | 30.21±34.55 | 81.77±30.27 | 66.92±36.82 | ||
| Median | 100.00 | 24.00 | 100.00 | 63.20 | ||
| Min-Max | 0.00-100.00 | 0.00-100.00 | 0.00-100.00 | 0.00-100.00 | ||
| NHP total | <0.001a | 0.012b | ||||
| Mean±SD | 242.75±114.33 | 88.95±95.13 | 298.70±128.30 | 219.86±100.93 | ||
| Median | 245.85 | 78.77 | 330.49 | 201.45 | ||
| Min-Max | 29.47-553.88 | 0.00-452.36 | 29.47-553.88 | 57.06-452.47 | ||
| MS: Multiple sclerosis; PDQ: The Pain Detect Questionnaire; SD: Standard deviation; EDSS: Expanded Disability Status Scale; FAC: Functional Ambulation Classification; ADL: Activities of Daily Living; FSS: Fatigue Severity Scale; BDI: Beck Depression Inventory; NHP: Nottingham Health Profile; a: Mann-Whitney U test; b: Student’s t-test. | ||||||