Fig. 2. Orai is involved in SOCE-induced airway smooth muscle contraction. (A) Representative traces of the contractile response induced by SOCE. (B) Representative traces of the contractile response induced by SOCE when the tracheas were incubated with the selective calcium-release activated Ca²⁺ channel blocker GSK5498A (10 μM) or BTP-2 (3 μM). (D) Statistical analysis showing the contractile response induced by SOCE under different conditions (n = 4-6). ^*P < 0.05 vs. the control group. Symbols and bars indicate the mean ± SD.

CCH, carbachol; SOCE, store-operated Ca²⁺ entry.