Fig. 3. Aerobic exercise relieved the SOCE-mediated ASM contraction of asthmatic rats through decreasing the secretion of IL-4. (A) Statistical analysis showing the secreted levels of IL-4 in the bronchoalveolar lavage fluid of each group (n = 5). (B) Representative traces and (C) statistical analysis of the [Ca2+]i response induced by SOCE when the ASM was incubated with IL-4 (500 ng/mL, 12 hours) (n = 5), **P < 0.01 vs. the control group. (D-G) Statistical analysis showing the SOCE-induced ASM contraction when the trachea was incubated with IL-4 (50–500 ng/mL, 12 hours, n = 4–8). *P < 0.05, **P < 0.01, ***P < 0.001 vs. the control group. Symbols and bars indicate the mean ± SD.
IL, interleukin; ns, not significant; SOCE, store-operated Ca2+ entry; ASM, airway smooth muscle.