Fig. 5. Proposed working model of the aerobic exercise reduces airway smooth muscle contraction in asthmatic rats. Aerobic exercise improved the ASM contractile function in asthmatic rats by inhibiting IL-4 secretion and down-regulating STIM1 and Orai (subtypes 1 and 2) expression levels, thereby decreasing excessive SOCE-mediated ASM contraction in asthmatic rats.
IL, interleukin; ASM, airway smooth muscle; STIM1, stromal interaction molecule 1; SOCE, store-operated Ca2+ entry.