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. Author manuscript; available in PMC: 2023 May 16.
Published in final edited form as: Biomed Mater. 2021 Feb 18;16(2):024103. doi: 10.1088/1748-605X/abdd70

Figure 4.

Figure 4.

In vivo CEST MRI detection of the delivery of citicoline-liposomes in rat brain after acute ischemic injury. (a) Chemical structure of citicoline, with CEST-generating exchangeable amine and hydroxyl protons are labeled in blue and red, respectively. (b) Citicoline is loaded into liposomes for simultaneous drug delivery and CEST MRI. (c) CEST MRI detection of citicoline in the regions undergoing ischemic stroke is accomplished in a label-free manner. Reprinted with permission from [38].