Table 4. Prodromal Feature Associations With Camp Lejeune in Veterans Without PD or Neurodegenerative Parkinsonism (n = 157 637)a.
| Feature | No. (%) | Lejeune, OR (95% CI) | P value |
|---|---|---|---|
| Tremor | 2318 (1.5) | 1.19 (1.09-1.29) | <.001 |
| Olfactory impairment | 686 (0.4) | 1.12 (0.96-1.30) | .14 |
| Erectile dysfunction | 32 424 (20.6) | 1.12 (1.09-1.14) | <.001 |
| Anxiety | 48 149 (30.5) | 1.08 (1.05-1.10) | <.001 |
| Seborrheic dermatitis | 5771 (3.7) | 1.04 (0.98-1.09) | .20 |
| Depression | 68 974 (43.8) | 1.02 (1.00-1.04) | .07 |
| Constipation | 15 860 (10.1) | 1.01 (0.98-1.04) | .63 |
| RBD | 134 (0.1) | 0.99 (0.70-1.39) | >.99 |
| Urinary dysfunction | 8699 (5.5) | 0.98 (0.94-1.03) | .39 |
| Internal prodromal risk score ≥99th percentileb | 1501 (1.0) | 1.14 (1.03-1.26) | .01 |
| MDS prodromal risk score ≥99th percentilec | 1332 (0.8) | 1.18 (1.06-1.32) | .003 |
Abbreviations: OR, odds ratio; RBD, rapid eye movement sleep behavior disorder.
a
Logistic regression models adjusted for age, sex, and race and ethnicity.
b
Prodromal risk score using internally derived likelihood ratios.
c
Prodromal risk score using MDS likelihood ratios.