FIGURE 3.

Identification of an aromatic box motif in C. concisus PglC. (a). AlphaFold model of Cc PglC with aromatic box residues highlighted in green, the Asp‐Glu catalytic dyad in cyan, and the C‐terminal loop in black. (b). Close‐up view of the aromatic box motif. (c). GREMLIN coevolution contact probabilities between residues in the aromatic box. Contact probability is defined as the probability of the residue pair being in contact, given the scaled score and the number of sequences per length.