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. 2023 May 3;6(5):842–853. doi: 10.1021/acsptsci.3c00053

Figure 1.

Figure 1

Amino acid sequences, structure of H2 relaxin, and predicted structures of H2 variants. (A) Primary sequence of human relaxin 2 (H2 relaxin) and its variants, H2 B-R13HR, H2 B-R17HR, and H2 B-R13/17HR. (B) Solution NMR structure of H2 relaxin (Protein Data Bank (PDB): 2MV1) and simulated structures of HR-incorporated H2 relaxin analogues. Structural estimation of HR substitution into H2 relaxin was achieved with PyMOL v 2.0 using the SwissSideChain plugin, and arginine residues were replaced with HR before the side chains were manually aligned to the original arginine side chain. (C) Structures of arginine (R) and homoarginine (HR).