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Post-translation modifications in the NICD. The NICD followed by its cleavage undergoes post-translational modifications like acetylation (responsible for finely tuning the half-life of Notch), hydroxylation (contributes to signaling diversity of NICD), methylation (increases stability and half-life of NICD), phosphorylation (regulates activity and turnover of NICD), and ubiquitination (activates Notch signaling, regulates the half-life of Notch).
