Two-dimensional structures of γ-secretase inhibitors of different
classes: (i) azepine (transition state analogues), e.g., LY411575
(A), and azepine (nontransition state analogues), e.g., DAPT (B);
(ii) sulfonamides (nontransition state analogues), e.g., MK0752 (C);
and (iii) peptide isoesterase (transition state analogues), e.g.,
GSI-1 (D). Two-dimensional structures of ADAM inhibitors, such as
ZLDI-8 (E), INCB3619 (F), and Marimastat (G). Two-dimensional structures
of γ-secretase modulators such as BPN15606 (H), Indomethacin
(I), GSM-1 (J), Tarenflurbil (K), E2012 (L), CHF5074 (M), SGSM36 (N),
FRM36143 (O), and BPN15606 (P).