Table 1.
Clinical features of invasive breast cancer patients in TCGA.
| Characteristic | Low Expression of TIGIT | High Expression of TIGIT | p |
|---|---|---|---|
| n | 532 | 533 | - |
| T stage, n (%) | - | - | 0.004 |
| T1 | 143 (13.5%) | 132 (12.4%) | - |
| T2 | 283 (26.6%) | 332 (31.3%) | - |
| T3 | 78 (7.3%) | 59 (5.6%) | - |
| T4 | 25 (2.4%) | 10 (0.9%) | - |
| N stage, n (%) | - | - | 0.467 |
| N0 | 259 (24.8%) | 248 (23.7%) | - |
| N1 | 171 (16.3%) | 178 (17%) | - |
| N2 | 50 (4.8%) | 66 (6.3%) | - |
| N3 | 38 (3.6%) | 36 (3.4%) | - |
| M stage, n (%) | - | - | 0.236 |
| M0 | 436 (48%) | 453 (49.8%) | - |
| M1 | 13 (1.4%) | 7 (0.8%) | - |
| Pathologic stage, n (%) | - | - | 0.059 |
| Stage I | 103 (9.9%) | 77 (7.4%) | - |
| Stage II | 287 (27.5%) | 319 (30.6%) | - |
| Stage III | 118 (11.3%) | 120 (11.5%) | - |
| Stage IV | 12 (1.2%) | 6 (0.6%) | - |
| Age, n (%) | - | - | 0.013 |
| <=60 | 273 (25.6%) | 315 (29.6%) | - |
| >60 | 259 (24.3%) | 218 (20.5%) | - |
| Histological type, n (%) | - | - | 0.917 |
| Infiltrating Ductal Carcinoma | 369 (38.5%) | 388 (40.5%) | - |
| Infiltrating Lobular Carcinoma | 97 (10.1%) | 105 (10.9%) | - |
| PR status, n (%) | - | - | < 0.001 |
| Negative | 138 (13.6%) | 200 (19.7%) | - |
| Indeterminate | 2 (0.2%) | 2 (0.2%) | - |
| Positive | 362 (35.6%) | 312 (30.7%) | - |
| ER status, n (%) | - | - | < 0.001 |
| Negative | 79 (7.8%) | 158 (15.5%) | - |
| Indeterminate | 1 (0.1%) | 1 (0.1%) | - |
| Positive | 423 (41.6%) | 355 (34.9%) | - |
| HER2 status, n (%) | - | - | 0.388 |
| Negative | 264 (36.8%) | 284 (39.6%) | - |
| Indeterminate | 6 (0.8%) | 6 (0.8%) | - |
| Positive | 66 (9.2%) | 91 (12.7%) | - |
| PAM50, n (%) | - | - | < 0.001 |
| Normal | 16 (1.5%) | 24 (2.3%) | - |
| LumA | 323 (30.3%) | 228 (21.4%) | - |
| LumB | 103 (9.7%) | 99 (9.3%) | - |
| Her2 | 25 (2.3%) | 57 (5.4%) | - |
| Basal | 65 (6.1%) | 125 (11.7%) | |
| Menopause status, n (%) | - | - | 0.209 |
| Pre | 104 (10.9%) | 120 (12.6%) | - |
| Peri | 24 (2.5%) | 15 (1.6%) | - |
| Post | 345 (36.1%) | 348 (36.4%) | - |
| Radiation_therapy, n (%) | - | - | 0.158 |
| No | 227 (23.4%) | 205 (21.1%) | - |
| Yes | 258 (26.5%) | 282 (29%) | - |
| OS event, n (%) | - | - | 0.049 |
| Alive | 447 (42%) | 471 (44.2%) | - |
| Dead | 85 (8%) | 62 (5.8%) | - |
| DSS event, n (%) | - | - | 0.233 |
| Alive | 475 (45.4%) | 490 (46.8%) | - |
| Dead | 46 (4.4%) | 35 (3.3%) | - |
| PFI event, n (%) | - | - | 0.103 |
| Alive | 451 (42.3%) | 471 (44.2%) | - |
| Dead | 81 (7.6%) | 62 (5.8%) | - |