Table 3.
Comparison of subject demographic, pulmonary function and imaging measurements for those with or without COPD and further those with or without chronic cough
| Parameter (±SD unless specified) | No COPD (n=583) | COPD (n=600) | ||||
| No chronic cough (n=518) |
Chronic cough (n=65) |
P value | No chronic cough (n=484) |
Chronic cough (n=116) |
P value | |
| Subject demographic | ||||||
| Age, years | 66 (9.7) | 67 (8.6) | 0.51 | 68 (10) | 67 (10) | 0.34 |
| Female sex, n (%) | 241 (47) | 26 (40) | 0.36 | 176 (36) | 48 (41) | 0.34 |
| Caucasian, n (%) | 484 (93) | 64 (98) | 0.16 | 457 (94) | 113 (97) | 0.24 |
| Pack-years, yrs | 10 (19) | 18 (27) | 0.03 | 20 (24) | 26 (26) | 0.03 |
| BMI, kg/m2 | 27 (4.8) | 28 (5.2) | 0.46 | 28 (5.3) | 27 (5.1) | 0.28 |
| Current-smoker, n (%) | 51 (9.8) | 13 (20) | 0.02 | 74 (15) | 39 (34) | <0.001 |
| History of asthma, n (%) | 42 (8.1) | 9 (14) | 0.16 | 112 (23) | 40 (34) | 0.02 |
| History of tuberculosis, n (%) | 3.0 (0.58) | 0.0 (0.0) | 1.00 | 10 (2.1) | 0 (0) | 0.22 |
| History of HDHTDM, n (%) | 177 (34) | 25 (38) | 0.49 | 190 (39) | 56 (48) | 0.09 |
| History of bronchiectasis, n (%) | 87 (17) | 14 (22) | 0.38 | 94 (19) | 29 (25) | 0.20 |
| Pulmonary function | ||||||
| FEV1, %pred | 104 (15) | 103 (16) | 0.71 | 87 (17) | 79 (15) | <0.001 |
| FEV1/FVC, % | 77 (4.6) | 76 (4.6) | 0.08 | 63 (6.5) | 61 (6.5) | 0.01 |
| RV/TLC, % | 37 (7.4) | 38 (7.8) | 0.39 | 42 (9.8) | 43 (9.1) | 0.15 |
| DLCO, %pred | 115 (22) | 106 (23) | 0.003 | 105 (24) | 95 (25) | <0.001 |
| BDR FEV1, % | 3.5 (5.8) | 4.1 (7.7) | 0.43 | 8.1 (9.1) | 6.7 (10) | 0.16 |
| BDR responder, n (%) | 52 (10) | 8.0 (12) | 0.52 | 166 (34) | 33 (28) | 0.27 |
| Imaging | ||||||
| LAA856, % | 20 (16) | 21 (17) | 0.49 | 30 (18) | 27 (16) | 0.05 |
| LAA950, % | 3.0 (3.1) | 3.1 (2.4) | 0.70 | 5.5 (5.0) | 4.9 (4.2) | 0.22 |
| TAC, n | 218 (69) | 231 (81) | 0.14 | 174 (62) | 176 (70) | 0.80 |
| Pi10, mm | 3.9 (0.14) | 3.9 (0.13) | 0.28 | 3.9 (0.14) | 3.9 (0.10) | 0.74 |
| Inner area, mm2 | 12 (4.0) | 13 (3.7) | 0.14 | 10 (3.0) | 10 (3.0) | 0.72 |
| Wall area per cent, % | 62 (2.9) | 62 (2.6) | 0.74 | 64 (2.9) | 64 (2.9) | 0.50 |
| DPM fSAD, % | 39 (17) | 38 (15) | 0.45 | 45 (15) | 45 (15) | 0.70 |
| PRM fSAD, % | 16 (13) | 19 (14) | 0.40 | 30 (17) | 23 (12) | 0.03 |
BDR, bronchodilator response; BMI, body mass index; COPD, chronic obstructive pulmonary disease; DLCO, diffusing capacity for carbon monoxide; DPM, disease probability measure; FEV1, forced expiratory volume in 1 s; fSAD, functional small airway disease; FVC, forced vital capacity; HDHTDM, heart disease, systemic hypertension or diabetes mellitus; LAA856, low attenuation area of the lung with attenuation values below−856 HU; %pred, per cent predicted; PRM, parametric response mapping; RV, residual volume; TAC, total airway count; TLC, total lung capacity.