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. 2023 May 12;11(5):e006774. doi: 10.1136/jitc-2023-006774

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Spatial analysis of high immune-infiltrated versus low immune-infiltrated regions of tumors after vaccination. (A) Pictures of region of interest (ROI) selection in a patient after vaccination. Upper ROI designates a tumor area with high immune-infiltration (ROI-H) while the lower ROI designates a tumor area with low immune-infiltration (ROI-L). (B) Box plots of differentially expressed (DE) proteins upregulated on vaccination (from figure 3 (n=4)). (C) Box plots of the downregulated DE proteins on vaccination (from figure 3 (n=4)). Differential expression of proteins depicted as boxplots showing median, upper and lower quartiles. Whiskers extend into a max of 1.5 times the IQR. HLA-DRA, Human Leukocyte Antigen DR alpha chain; KRT1, keratin 1; MKI67, marker Ki-67; PD-L1, programmed death-ligand 1.