Table 2. Summary of ICG administration in gastric cancer.
| Authors | Aim | Concentration | Dosage | Time of injection | Injection method | Injection location |
|---|---|---|---|---|---|---|
| Cho et al. (4) | Determine tumor location | 0.625 mg/mL | 0.6 mL per site | 1 day before surgery | Endoscopic injection of submucosa | 4 sites around the tumor |
| Miyashiro et al. (7) | Identifying the sentinel lymph nodes | 0.5–2.5 mg/mL | 2–4 mL in total | During surgery | Endoscopic injection | 4–8 sites around the tumor |
| Nakanishi et al. (26) | Determine tumor location | 1.0 mg/mL | 0.1 mL per site | 1–3 days before surgery | Endoscopic injection of submucosa | 1 site around the tumor |
| Yoon et al. (38) | Determine tumor location | 0.5 mg/mL | 0.1 mL per site | 1 day before surgery | Endoscopic injection of submucosa | 4 sites around the tumor |
| Ushimaru et al. (39) | Determine tumor location | 0.05 mg/mL | 0.5 mL per site | 1 day before surgery | Endoscopic injection of submucosa | 4 sites around the tumor |
| Miyashiro et al. (59) | Identifying the sentinel lymph nodes | 5 mg/mL | 4–5 mL in total | During surgery | Subserosal injection | Multiple sites around the tumor |
| Kwon et al. (67) | Lymph node imaging | 1.25 mg/mL | 0.6 mL per site | 1 day before surgery | Endoscopic submucosal injection | 4 sites around the tumor |
| Chen et al. (68) | Lymph node imaging | 1.25 mg/mL | 0.5 mL per site | 1 day before surgery | Endoscopic submucosal injection | 4 sites around the tumor |
| Puccetti et al. (70) | Lymph node imaging | 0.125 mg/mL | 0.5 mL per site | 12–24 h before surgery | Endoscopic submucosal injection | 4 sites around the tumor |
| Zhong et al. (71) | Lymph node imaging | 1.25 mg/mL | 0.5 mL per site | 1 day before surgery | Endoscopic submucosal injection | 4 sites around the tumor |
| Zhong et al. (71) | Lymph node imaging | 0.5 mg/mL | 1.5 mL per site | 20 min before lymph nodes dissection | Subserous injection under laparoscope | 6 sites of the lesser and greater curvature |
| Huang et al. (77) | Lymph node imaging | 0.5 mg/mL | 1.5 mL per site | After preoperative exploration | Subserous injection under laparoscope | 6 sites of the lesser and greater curvature |
| Tanaka et al. (120) | Determine tumor location | 1 mg/mL | 0.1 mL per site | 1–3 days before surgery | Endoscopic injection of submucosa | 1 site around the tumor |
| Lombardi et al. (121) | Lymph node imaging | 0.125 mg/mL | 0.5 mL per site | Within 20 hours before surgery | Endoscopic submucosal injection | 4 sites around the tumor |
| Chen et al. (122) | Determine tumor location and lymph node imaging | 1.25 mg/mL | 0.5 mL per site | 1 day before surgery | Endoscopic injection of submucosa | 4 sites around the tumor |
| Yano et al. (123) | Identifying the sentinel lymph nodes | 0.5 mg/mL | 0.5 mL per site | During surgery | Endoscopic injection | 4 sites around the tumor |
| Ohdaira et al. (124) | Identifying the sentinel lymph nodes | 5 mg/mL | 0.5 mL per site | During surgery | Endoscopic submucosal injection | 4 sites around the tumor |
| Maruri et al. (125) | Lymph node imaging | 1.25 mg/mL | 0.6 mL per site | 18–24 h before surgery | Endoscopic submucosal injection | 4 sites around the tumor |
| Cianchi et al. (126) | Lymph node imaging | 1.25 mg/mL | 0.5 mL per site | 1 day before surgery | Endoscopic submucosal injection | 4 sites around the tumor |
ICG, indocyanine green.