Figure 6.

Schematic illustration of the fabrication of the Fe-based nanomaterials modified 3D bioceramic scaffolds for MTT: (a) fabrication of the β-TCP scaffolds coated with a GO-Fe₃O₄-GO layer and its use in the treatment of osteosarcoma by combining PTT with MTT, (b) schematic diagram of the fabrication of Fe-doped AKT scaffolds and dual function of Fe in PTT and MTT, (c) schematic representation of the anti-tumor and bone-regeneration ability of 3D-printed AKT scaffolds loaded with Fe₃O₄ and CaO₂ nanoparticles. CaO₂ nanoparticles generated ample H₂O₂ in an acidic tumor microenvironment. Fe₃O₄ nanoparticles catalyze a Fenton-like reaction to convert H₂O₂ to •OH. This reaction shows the potential of Fe₃O₄ in combining chemodynamical properties with magnetotherapy against osteosarcoma. Cited with permission. ⁹⁵ Copyright 2016, J. Mater. Chem. B. ⁹² Copyright 2019, American Chemical Society. ⁵² Copyright 2019, Adv. Funct. Materials.