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. 2023 May 15;23:442. doi: 10.1186/s12885-023-10938-8

Table 2.

Input parameters in the partitioned survival model

Baseline value ($) Range ($) Distribution Reference
Durvalumab 7,866.6/ 1,500 mg 5,899.95–9,833.25 lognormal [20]
Atezolizumab 4,755/1,200 mg 3,566.25–5,943.75 lognormal [20]
Pembrolizumab 2,612.83/100 mg 1,959.69–3,266.11 lognormal [27]
Nivolumab 665/40 mg 498.75–831.25 lognormal [20]
Ipilimumab 81.2/mg 60.9–101.5 lognormal [20]
Sintilimab 157.5/100 mg 118.13–196.88 lognormal [28]
Camrelizumab 426.9/200 mg 320.2–533.7 lognormal [29, 30]
Tislelizumab 317.89/100 mg 238.42–397.36 lognormal [31]
Bevacizumab 262.5/100 mg 196.88–328.13 lognormal [32]
Tremelimumaba 81.2/mg 60.9–101.5 lognormal -
Carboplatin 0.16/mg 0.12–0.21 lognormal [27]
Pemetrexed 131.24/100 mg 98.43–164.05 lognormal [32]
Docetaxel 189.57/200 mg 142.18–236.96 lognormal [33]
Cost of medical service of immunotherapy per cycle 8.20 6.15–10.25 lognormal [27]
Cost of medical service of chemotherapy per cycle 45.97 34.48–57.47 lognormal [27]
Follow-up cost per cycle 58.53 43.90–73.17 lognormal [27, 34]
Utility for PFS 0.804 0.683–0.925 beta [35]
Utility for PD 0.321 0.273–0.369 beta [35]
Utility for death 0 0 - -
Discount rate 5% 0–8% - [25]

aThe price of tremelimumab was assumed to be identical to that of ipilimumab, because tremelimumab was not approved to enter into the market