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. 2023 May 16;22:84. doi: 10.1186/s12943-023-01768-0

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — The epigenetic sensitization effect of immunotherapy was eliminated in Runx3^{fl/fl;Lck-Cre} mice. a Workflow of the construction of Runx3 conditional knockout mice and analysis of the tumor growth curve in Runx3^fl/fl and Runx3^{fl/fl;Lck-Cre} mice treated with anti-PD-1(n=5, two-tailed unpaired t tests, **P< 0.01). Upper panel: average tumor growth curves; lower panel: individual tumor growth curves. b Analysis of the tumor growth curve in Runx3^fl/fl and Runx3^{fl/fl;Lck-Cre} mice treated with anti-PD-1or DAC+ anti-PD-1(n=5,two-tailed unpaired t tests, **P<0.01). Upper panel: average tumor growth curves; lower panel: individual tumor growth curves. c tSNE analysis of immune cell subsets in the CD8+Tils of Runx3^fl/fl and Runx3^{fl/fl;Lck-Cre} mice treated with anti-PD-1. Upper panel: tSNE data showing the overall distribution of each subgroup. Lower panel: Histogram showing the absolute numbers of cells of various subtypes (cell number/10⁴ CD45+ cells). d tSNE analysis of immune cell subsets in the CD8+ Tils of Runx3^fl/fl and Runx3^{fl/fl;Lck-Cre} mice treated with DAC+anti- PD-1. Upper panel: tSNE data showing the overall distribution of each subgroup. Lower panel: Histogram showing the absolute numbers of cells of various subtypes (cell number/10⁴ CD45+ cells)