Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 May 16;22:84. doi: 10.1186/s12943-023-01768-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 5 — Runx3 deletion hampers CCRs expression and tumor infiltration of CD8+ T cells. a Determination of immune cell subsets in the peripheral blood and spleen of Runx3^fl/fl and Runx3^{fl/fl;Lck-Cre} (Runx3^CKO)mice by tSNE analysis after mass cytometry. Left panel: tSNE data showing the overall distribution of each subgroup. Right panel: The histogram shows the absolute numbers of cells of various subtypes (cell number/10⁴ CD45+ cells). b CD8+ T cells distribution in the tumor tissue of Runx3^fl/fl and Runx3^CKO mice by tSNE analysis. c tSNE plots showing Runx3 and CCRs expression of T cells after anti-PD-1/DAC treatment. The plots represented CD45+ immune cells in mice tumors, and the circle indicated CD8+ T cell population. d tSNE plots showing expression of marker genes of T cells after anti-PD-1/DAC treatment. The plots represented CD45+ immune cells in mice tumors, and the circle indicated CD8+ T cell population. e Schematic illustration showing that demethylation of Runx3 by DAC promoted CCRs expression and T-cell infiltration