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. 2023 May 16;22:84. doi: 10.1186/s12943-023-01768-0

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Runx3 is a key molecular marker of the clinical response to immunotherapy. a Violin diagram showing the expression levels of Runx3, CD28, CD226, FasL and STAT4 in T cells in responders and nonresponders. The figure shows the median, upper quartile and lower quartile. Two-tailed unpaired t tests. b Correlation analysis between effector T cells, memory T cells and Runx3. The x-axis represents Runx3 expression in T cells, and the y-axis represents the abundance of memory T cells or effector T cells. c. Kaplan‒Meier survival curves between high and low expression of Runx3 in T cells and prognoses in different cancer types