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. Author manuscript; available in PMC: 2023 May 16.
Published in final edited form as: Nat Neurosci. 2022 Aug 30;25(9):1191–1200. doi: 10.1038/s41593-022-01146-x

Extended Data Fig. 8 ∣. Effects of the combined CRF and (2R,6R)-hydroxynorketamine on field excitatory postsynaptic potentials in hippocampal slices in the SC-CA1 pathway.

Extended Data Fig. 8 ∣

(a) Representative traces of Schaffer collateral-hippocampal CA1 (SC-CA1) field excitatory postsynaptic potentials (fEPSPs) and (b) quantification of fEPSPs slopes following SC-CA1 pathway stimulation during wash-in with Saline (SAL; n = 11 slices), corticotropin-releasing factor (CRF; 125 nM; n = 12 slices), (2R,6R)-hydroxynorketamine (HNK; 15 μM; n = 11 slices) or combined CRF (125 nM) + (2R,6R)-HNK (15 μM) (n = 11 slices; two-sided one-way ANOVA followed by Holm-Sidak test; SAL vs HNK p = 0.0053, SAL vs CRF+ HNK p = 0.0003, CRF vs HNK p = 0.0043, CRF vs CRF + HNK p = 0.0002). Data are shown as mean ± S.E.M. ** p < 0.01. For detailed statistics information, see Supplementary Table 1.