Table III.
Multivariable log-binomial regression results of outcomes associated with children admitted to CHCO with RSV, influenza, or COVID-19 from October 1, 2021, to April 30, 2022, (n = 847)
| Outcomes | Unadjusted |
Adjusted |
||
|---|---|---|---|---|
| RR | 95% CI (P value) | RR | 95% CI (P value) | |
| ICU admission∗ | ||||
| SARS-CoV-2 | 1.0 (ref) | - | 1.0 (ref) | - |
| RSV | 1.07 | 0.84-1.35 (0.59) | 0.85 | 0.66-1.09 (0.19) |
| Influenza | 1.29 | 0.84-1.99 (0.25) | 1.97 | 1.22-3.19 (0.01) |
| Pneumonia diagnosis† | ||||
| SARS-CoV-2 | 1.0 (ref) | - | 1.0 (ref) | - |
| RSV | 1.60 | 1.09-2.37 (0.018) | 2.32 | 1.54-3.52 (<.0001) |
| Influenza | 0.77 | 0.28-2.09 (0.61) | 1.05 | 0.39-2.85 (0.92) |
| Bronchiolitis diagnosis‡ | ||||
| SARS-CoV-2 | 1.0 (ref) | - | 1.0 (ref) | - |
| RSV | 4.62 | 3.51-6.06 (<.0001) | 2.93 | 2.28-3.78 (<.0001) |
| Influenza | 0.65 | 0.27-1.56 (0.33) | 1.10 | 0.49-2.48 (0.82) |
| Hospital length of stay >4 days§ | ||||
| SARS-CoV-2 | 1.0 (ref) | - | 1.0 (ref) | - |
| RSV | 1.31 | 1.06-1.62 (0.012) | 1.40 | 1.12-1.76 (0.00) |
| Influenza | 0.76 | 0.44-1.32 (0.33) | 0.91 | 0.51-1.62 (0.75) |
| High-flow oxygen support or mechanical ventilation (noninvasive and invasive)¶ | ||||
| SARS-CoV-2 | 1.0 (ref) | - | 1.0 (ref) | - |
| RSV | 2.25 | 1.75-2.90 (<.0001) | 2.01 | 1.54-2.63 (<.0001) |
| Influenza | 0.72 | 0.35-1.50 (0.38) | 1.17 | 0.58-2.36 (0.66) |
∗
ICU admission adjusted for prematurity, immunocompromised condition, and race/ethnicity.
†
Pneumonia diagnosis adjusted for CLD, and race/ethnicity.
‡
Bronchiolitis diagnosis adjusted for prematurity, CLD, and neurological condition.
§
Hospital length of stay >4 days adjusted for prematurity and bacterial coinfection.
¶
High-flow oxygen support or greater adjusted for prematurity and bacterial coinfection.