| ACAM2000 |
Replication‐competent Recombinant vaccinia viruses make VACV vaccinations typically safe and effective. Since the vaccine does not include the variola virus, it cannot cause smallpox. It is provided as a lyophilized powder reconstituted with a packed diluent. |
Possible adverse effects include itchiness, swelling (lymphadenopathy), pain (administration site), fever, headaches, myalgia, weakness (fatigue), and infection (bacteria). Other severe adverse reactions to vaccinations, in addition to myopericarditis and pericarditis, include encephalitis, progressive vaccinia, erythema multiforme major, eczema, vaccinatum, generalized vaccinia, post-vaccinal encephalitis or encephalomyelitis, blindness from autoinoculation, and fetal death in expectant mothers. |
| LC16m18 |
Since it was successfully given to more than 50,000 children in the 1970s, LC16m8, an attenuated, replicating smallpox vaccine developed from the Lister strain of vaccinia, has been licensed in Japan. In nonclinical studies, it was found to have significantly less neurotoxicity than vaccines that had not been attenuated. Recent research in two different animal models has shown that LC16m8 is immunogenic after a single dose and has protective efficacy comparable to the only smallpox vaccine approved by the FDA. |
Common adverse effects include weariness, pruritus, lymphadenopathy, pain at the injection site, fever, headache, myalgia, and rash. |
| JYNNEOS |
People with immune weaknesses may be vaccinated with a live, attenuated, replication-deficient vaccine since it has fewer side effects than some others and no serious adverse events. |
Side effects that are often experienced include myalgia, headaches, tiredness, nausea, and chills. Clinical studies did not have a sufficient number of participants 65 years of age and over, which cannot be established by adequate human studies. The human data on expectant mothers that are currently available are insufficient to determine the risks of vaccination during pregnancy, and it is unknown if the vaccine is excreted in human milk. Individuals under 18 have not been studied for safety and efficacy. |
