Table 4.

The top 20 significantly upregulated pathways in TB model group and their changes in various ag85a/b DNA vaccine groups.

Pathway ID	Definition	Enrichment score of the pathway
		TB model group versus Normal group	DNA IM group versus TB model group				DNA EP group versus TB model group
			10 μg	50 μg	100 μg	200 μg	10 μg	50 μg	100 μg	200 μg
mmu04972	Pancreatic secretion	11.335708↑	NO	NO	13.494424↓	11.410462↓	15.449871↓	13.102152↓	10.378839↓	11.678653↓
mmu04974	Protein digestion and absorption	6.798788↑	NO	NO	9.228974↓	7.719846↓	7.406446↓	8.944734↓	7.665778↓	7.913878↓
mmu04975	Fat digestion and absorption	4.937938↑	NO	NO	4.715005↓	4.016645↓	4.29808↓	4.584038↓	3.991484↓	4.106856↓
mmu04911	Insulin secretion	3.887882↑	NO	NO	4.053136↓	4.653304↓	4.676213↓	NO	4.615988↓	4.039977↓
mmu04080	Neuroactive ligand‐receptor interaction	3.434282↑	NO	NO	3.895453↓	6.009911↓	3.649268↓	NO	3.434282↓	4.641685↓
mmu04950	Maturity onset diabetes of the young	3.101886↑	NO	NO	5.934764↓	5.205878↓	4.619483↓	NO	4.097165↓	6.481842↓
mmu00561	Glycerolipid metabolism	2.924039↑	NO	NO	2.069674↓	1.636779↓	1.987283↓	NO	1.621508↓	1.691735↓
mmu04713	Circadian entrainment	2.7979↑	NO	NO	2.297331↓	NO	2.188517↓	NO	2.228↓	1.802273↓
mmu05030	Cocaine addiction	2.644894↑	NO	NO	2.414299↓	1.960102↓	1.619297↓	2.710407↓	1.943952↓	1.38322↓
mmu05164	Influenza A	2.532544↑	NO	NO	1.508885↓	NO	1.40679↓	NO	NO	NO
mmu04917	Prolactin signaling pathway	2.354739↑	NO	NO	2.299486↓	2.376645↓	2.202203↓	NO	NO	1.322084↓
mmu04010	MAPK signaling pathway	2.327035↑	NO	NO	NO	NO	1.559062↓	NO	NO	NO
mmu04970	Salivary secretion	2.2593↑	NO	1.541781↓	2.215196↓	1.712174↓	1.5306↓	NO	NO	NO
mmu04710	Circadian rhythm	1.987694↑	NO	NO	NO	NO	NO	NO	NO	1.309626↓
mmu04912	GnRH signaling pathway	1.949105↑	NO	NO	NO	NO	1.847607↓	NO	1.443851↓	NO
mmu05031	Amphetamine addiction	1.941061↑	NO	NO	NO	1.403914	NO	NO	1.941061↓	1.456146↓
mmu04728	Dopaminergic synapse	1.883599↑	NO	NO	2.070013↓	1.477067↓	2.184166↓	1.486645↓	1.883599↓	NO
mmu05032	Morphine addiction	1.825693↑	NO	NO	2.423023↓	1.845834↓	2.66319↓	NO	NO	NO
mmu04614	Renin‐angiotensin system	1.804049↑	NO	NO	4.057283↓	3.460628↓	2.788612↓	2.121122↓	5.399902↓	2.656079↓
mmu04961	Endocrine and other factor‐regulated calcium reabsorption	1.772715↑	NO	NO	3.847204↓	3.181395↓	3.448604↓	2.897346↓	4.808097↓	3.266867↓

Abbreviations: DE, differentially expressed; EP, electroporation; IM, intramuscular injection; TB, tuberculosis; ↑, upregulated score; ↓, downregulated score.