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. 2023 May 15;38(1):2205042. doi: 10.1080/14756366.2023.2205042

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© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 7. — The screening hit compound P25 potently and dose-dependently (0, ½IC₅₀, IC₅₀, and 1½IC₅₀) inhibits the migration of A431 (A; top panel) and SKMEL-28 (A; bottom panel) cells into the cell-free scratched-wounded areas of a confluent cell monolayer. This suppression of A431 and SKMEL-28 cells scratch wound closure in a concentration-dependent manner was significant. The bar graphs (B) represent the mean ± SD of covered scratch-wound area values (expressed as the migrated distance from 0-time point of scratch) after 48 h. They are expressed as a percentage of wound area at 0 h filled by migrated cells by the end of the experiment, vs. the same indicator for untreated control cells, from three independent experiments conducted in triplicate. Statistical significance was assessed using one-way ANOVA and Tukey’s multiple comparison tests; **p < 0.01, and ***p < 0.001 were considered significant.