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. 2023 May 2;14:1183983. doi: 10.3389/fimmu.2023.1183983

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Copyright © 2023 Serwanga, Baine, Mugaba, Ankunda, Auma, Oluka, Kato, Kitabye, Sembera, Odoch, Ejou, Nalumansi, Gombe, Musenero, Kaleebu and the COVID-19 Immunoprofiling Team

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Median fold change in in spike-directed antibody levels over time. Figure 6 summarises the fold change in spike-directed IgG, IgM and IgA antibody OD values (A) and concentrations (B) across the different specimen collection time points. The heat map shows the extent of change (increase or decrease) in vaccine-induced antibody response over time. The change between time points is shown with each cell indicating an increase or decrease between any two timepoints at the x and y axis. Fold change between 0 to 1 indicate a decrease (orange), Fold change of 1 indicates no change while fold change greater than 1 indicate an increase (purple).