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[Preprint]. 2023 Sep 17:2023.05.02.539023. Originally published 2023 May 2. [Version 2] doi: 10.1101/2023.05.02.539023

PMC10187181.1; 2023 May 2
PMC10187181.2; 2023 Sep 17

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Figure 1. — (A-F) Integrin domain organization and conformational changes during activation are depicted for both αI-less (A-C) and αI-containing (D-F) integrins. The figures illustrate global and local structural changes, with dashed lines representing alternative conformations of the β leg domains. (G) The integrin family and overall structures of α and β subunits predicted by AlphaFold2 are displayed, with the red line marketing the boundary between the extracellular and transmembrane (TM) domains. The structure images are color-coded based on model confidence calculated as pLDDT scores.