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[Preprint]. 2023 May 2:2023.05.01.538955. [Version 1] doi: 10.1101/2023.05.01.538955

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Figure 4: — Vaccination in pregnancy enhances RBD IgG1. The magnitude of RBD-specific total IgG and subclasses in (A) cord and (B) maternal responses are shown. P-values are adjusted for maternal age and body mass index using linear regression. Radar plots summarize the magnitude of RBD-specific isotype and subclass. Each line represents the median Z-scored data for each clinical group (infection n=20, vaccine n=18, vaccine+infection n=27). Heatmaps of the regression coefficients (r²) summarize the dependency of RBD-specific antibody functions on subclasses in cord (C) and maternal (D) samples by simple linear regression. * p≤0.05; ** p≤0.01; *** p≤0.001; **** p≤0.0001.