Figure 2. SV discovery.

a) Venn diagram comparing Sniffles detection of SVs (both insertions and deletions) for 30X HiFi and 30X standard ONT input readsets. Of the variants unique to one technology or the other, 85% map to tandem repeat regions, which suggests breakpoint resolution rather than technology-specific bias is driving the difference. b) Venn diagram comparing Sniffles SV discovery at 12X and 30X HiFi callsets. A consistent set of calls is generated above 12X.