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[Preprint]. 2023 May 4:2023.05.04.539391. [Version 1] doi: 10.1101/2023.05.04.539391

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Figure 4. — Genetic control of the Pol4-independent, 29-bp deletion. (A) Mean frequencies of Lys⁺ colonies; error bars are 95% confidence intervals for the means. (B) The overall distribution of the three major NHEJ types in each mutant background. With the ACGAAT spacer only the 2A>3A, the 29-bp deletion, and random “other” events were observed; there were no 1T>2T or +CGAA events. Changing the ACGAAT spacer to ACGTAT eliminated the 2A>3A event (orange cross-hatched), which was replaced by +CGTA (blue). Each distribution was compared to the corresponding WT using a 2 × 3 contingency chi square test (ns, not significant). If the global p value (above each spectrum) was less than 0.05, individual mutation classes were compared using the Bonferroni correction to determine significance (p < 0.05/3); asterisks indicate a significant proportional increase/decrease.