Figure 2. Molecular landscape of baseline prostate tumors prior to undergoing RT.

Up to four biopsies were acquired per patient and subjected to whole-exome sequencing and transcriptome profiling on the Affymetrix Human Exon 1.0 array. Samples are grouped by outcome and separated by patient. Alterations in previously-identified prostate cancer MutSig genes are shown. From each case, a single biopsy was selected using predefined criteria, consisting of the most adverse phenotypes, for patient-level prognostication. Alteration enrichments were determined using a two-sided Fisher’s exact test with (Q) or without (P) Benjamini-Hochberg correction.