Table 3.

Significance and direction of CHD DMRs and background regions in DS vs TD samples

	DMRs	Background Regions
Sex Combined	n (%)	n (%)
Total	58	5,363
Omitted	0	28
p < 0.05	16 (27.6)	995 (18.7)
p ≥ 0.05	42 (72.4)	4,340 (81.3)
Same direction	34 (58.6)	3,274 (61.4)
Opposite direction	24 (41.4)	2,061 (38.6)
Females Only	n (%)	n (%)
Total	341	11,998
Omitted	2	147
p < 0.05	42 (12.4)	1,101 (9.3)
p ≥ 0.05	297 (87.6)	10,750 (90.7)
Same direction	172 (50.7)	6,304 (53.2)
Opposite direction	167 (49.3)	5,547 (46.8)
Males Only	n (%)	n (%)
Total	3,938	127,819
Omitted	26	1,413
p < 0.05	602 (15.4)	18,099 (14.3)
p ≥ 0.05	3,310 (84.6)	108,307 (85.7)
Same direction	3,001 (76.7)	90,954 (72.0)
Opposite direction	911 (23.3)	35,452 (28.0)

Same direction indicates methylation is in same direction (hypo or hyper) in DS vs TD as in DS-CHD vs non-CHD