Table 2.
Baseline Population Characteristics Before and After Matching
| Before Matching |
After Matching |
|||
|---|---|---|---|---|
| Characteristic | No Paxlovid (N= 521,379) |
Paxlovid (N=111,443) |
No Paxlovid (N=306,132) |
Paxlovid (N=104,510) |
| Hospitalization1 | ||||
| No | 510,706 (98.0%) | 110,745 (99.4%) | 300,583 (98.2%) | 103,882 (99.4%) |
| Yes | 10,673 (2.0%) | 698 (0.6%) | 5,549 (1.8%) | 628 (0.6%) |
| Sex | ||||
| Female | 315,078 (60.4%) | 67,597 (60.7%) | 189,642 (61.9%) | 63,914 (61.2%) |
| Male | 206,198 (39.5%) | 43,829 (39.3%) | 116,490 (38.1%) | 40,596 (38.8%) |
| Missing | 103 (0.0%) | <20 (0.0%) | - | - |
| Age (in years) | ||||
| 18-24 | 15,963 (3.1%) | 1,429 (1.3%) | 3,757 (1.2%) | 1,018 (1.0%) |
| 25-34 | 35,194 (6.8%) | 4,538 (4.1%) | 11,921 (3.9%) | 3,657 (3.5%) |
| 35-49 | 70,172 (13.5%) | 12,716 (11.4%) | 34,950 (11.4%) | 11,172 (10.7%) |
| 50-64 | 215,304 (41.3%) | 42,112 (37.8%) | 127,144 (41.5%) | 40,101 (38.4%) |
| 65+ | 184,746 (35.4%) | 50,648 (45.5%) | 128,360 (41.9%) | 49,562 (47.4%) |
| Missing | - | - | - | - |
| Race/Ethnicity2 | ||||
| Asian (NH) | 11,082 (2.1%) | 3,594 (3.2%) | 3,393 (1.1%) | 2,544 (2.4%) |
| Black or African American (NH) | 74,907 (14.4%) | 10,627 (9.5%) | 27,638 (9.0%) | 9,457 (9.0%) |
| Hispanic or Latino (Any Race) | 49,908 (9.6%) | 8,332 (7.5%) | 18,638 (6.1%) | 7,021 (6.7%) |
| White (NH) | 335,385 (64.3%) | 81,891 (73.5%) | 235,601 (77.0%) | 80,081 (76.6%) |
| Other (NH) | 5,716 (1.1%) | 920 (0.8%) | 978 (0.3%) | 502 (0.5%) |
| Unknown | 44,381 (8.5%) | 6,079 (5.5%) | 19,884 (6.5%) | 4,905 (4.7%) |
| Charlson Comorbidity Index | ||||
| 0 | 194,689 (37.3%) | 46,596 (41.8%) | 126,679 (41.4%) | 44,822 (42.9%) |
| 1-2 | 188,703 (36.2%) | 42,488 (38.1%) | 119,336 (39.0%) | 40,479 (38.7%) |
| 3-4 | 54,101 (10.4%) | 11,228 (10.1%) | 29,086 (9.5%) | 9,914 (9.5%) |
| 5-10 | 32,788 (6.3%) | 5,513 (4.9%) | 15,113 (4.9%) | 4,648 (4.4%) |
| 11+ | 3,644 (0.7%) | 523 (0.5%) | 638 (0.2%) | 296 (0.3%) |
| Missing | 47,454 (9.1%) | 5,095 (4.6%) | 15,280 (5.0%) | 4,351 (4.2%) |
| Community Wellbeing Index3 | ||||
| 0-45 | 2,646 (0.5%) | 275 (0.2%) | 327 (0.1%) | 157 (0.2%) |
| 46-55 | 152,670 (29.3%) | 26,978 (24.2%) | 91,926 (30.0%) | 25,470 (24.4%) |
| 56-65 | 193,631 (37.1%) | 46,639 (41.9%) | 106,456 (34.8%) | 43,891 (42.0%) |
| 66-100 | 26,644 (5.1%) | 9,961 (8.9%) | 13,750 (4.5%) | 8,879 (8.5%) |
| Missing | 145,788 (28.0%) | 27,590 (24.8%) | 93,673 (30.6%) | 26,113 (25.0%) |
| Month of COVID-19 diagnosis | ||||
| December 2021 | 39,670 (7.6%) | 77 (0.1%) | - | - |
| January 2022 | 166,565 (31.9%) | 1,544 (1.4%) | 902 (0.3%) | 64 (0.1%) |
| February 2022 | 37,600 (7.2%) | 931 (0.8%) | 69,739 (22.8%) | 1,495 (1.4%) |
| March 2022 | 11,775 (2.3%) | 845 (0.8%) | 16,468 (5.4%) | 865 (0.8%) |
| April 2022 | 16,902 (3.2%) | 3,805 (3.4%) | 4,226 (1.4%) | 725 (0.7%) |
| May 2022 | 38,567 (7.4%) | 12,984 (11.7%) | 10,782 (3.5%) | 3,420 (3.3%) |
| June 2022 | 39,959 (7.7%) | 14,950 (13.4%) | 31,292 (10.2%) | 12,227 (11.7%) |
| July 2022 | 45,957 (8.8%) | 19,455 (17.5%) | 32,867 (10.7%) | 14,135 (13.5%) |
| August 2022 | 39,646 (7.6%) | 16,128 (14.5%) | 39,158 (12.8%) | 18,580 (17.8%) |
| September 2022 | 26,454 (5.1%) | 11,101 (10.0%) | 32,965 (10.8%) | 15,303 (14.6%) |
| October 2022 | 20,185 (3.9%) | 8,386 (7.5%) | 20,819 (6.8%) | 10,338 (9.9%) |
| November 2022 | 18,149 (3.5%) | 9,131 (8.2%) | 15,889 (5.2%) | 7,766 (7.4%) |
| December 2022 | 19,950 (3.8%) | 12,106 (10.9%) | 14,412 (4.7%) | 8,275 (7.9%) |
1
Any hospital admission in the 28-days following a positive SARS-CoV-2 test result
2
abbrev. NH = Non-Hispanic.
3
Community Wellbeing Index (CWBI) is a measure of five inter-related community-level domains, with higher CWBI values corresponding to a higher level of protective community-level social determinants of health. 32