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. 2023 May 16;19(7):407–424. doi: 10.1038/s41574-023-00822-7

Fig. 2. Chemical structures of compounds that act as ligands for ERα, ERβ and/or GPER.

Fig. 2

Shown are examples of natural steroids, phytooestrogens, xenooestrogens/endocrine disrupting chemicals (EDCs), therapeutic agents and experimental compounds that display varying activities towards oestrogen receptor-α (ERα), oestrogen receptor-β (ERβ) and the G protein-coupled oestrogen receptor (GPER) but are generally non-selective. Also shown are synthetic experimental compounds that exhibit selectivity for ERα and/or ERβ, such as propylpyrazoletriol (PPT), diarylpropionitrile (DPN) and AB-1, or for GPER, such as G-1, G15, G36 and CIMBA. p,p′-DDT, p,p′-dichlorodiphenyltrichloroethane.