Table 3.

Results of cross-sectional and longitudinal analyses of the associations between serum adiponectin and AV-1451, AD-CM, AD-CT, or WMH volume in cognitively normal individuals.

	AV-1451, SUVR		AD-CM, SUVR		AD-CT, mm		WMH volume, cm3
	β	p-value	β	p-value	β	p-value	β	p-value
Model 1a	0.227	0.087	-0.070	0.314	-0.145	0.040*	0.051	0.473
Model 2b	0.144	0.286	-0.018	0.802	-0.039	0.553	0.017	0.811
Model 3c	0.132	0.553	-0.079	0.361	-0.023	0.777	0.027	0.771
	ΔAV-1451, SUVR		ΔAD-CM, SUVR		ΔAD-CT, mm		ΔWMH volume, cm3
	β	p-value	β	p-value	β	p-value	β	p-value
Model 1a	0.171	0.326	0.074	0.350	0.076	0.353	-0.058	0.478
Model 2b	0.289	0.095	0.016	0.837	0.077	0.369	-0.101	0.219
Model 3c	0.066	0.789	0.053	0.560	0.106	0.319	-0.125	0.235

Aβ=beta-amyloid, AD-CM=Alzheimer’s disease signature cerebral glucose metabolism, AD-CT=Alzheimer’s disease signature cortical thickness, WMH=white matter hyperintensity, =standardized beta coefficients.

^aNot adjusted.

^bAdjusted for age, sex, and APOE4.

^cAdjusted for age, sex, APOE 4, education, GDS score, VRS, BMI, annual income, LPA, albumin, fasting glucose, HDL- and LDL-cholesterol, HOMA-IR, zinc, alcohol intake, and smoking.

^*p < 0.05,

^**p < 0.01,

^***p < 0.001.