Table 6.
Cross-sectional and longitudinal moderation effects of age, sex, APOE4, education, GDS, VRS, BMI, annual income, lifetime physical activity, albumin, fasting glucose, HDL-and LDL-cholesterol, and HOMA-IR on association between serum adiponectin and global Aβ retention in cognitively normal individuals.
| Global Aβ retention, SUVR | Δ global Aβ retention, SUVR | |||
|---|---|---|---|---|
| β | p-value | β | p-value | |
| Adiponectin | -0.314 | 0.074 | -0.301 | 0.139 |
| Age | 0.047 | 0.510 | -0.012 | 0.896 |
| Adiponectin×Age | 0.580 | 0.002** | 0.468 | 0.030* |
| Adiponectin | 0.119 | 0.212 | 0.084 | 0.382 |
| Sex | -0.090 | 0.484 | 0.015 | 0.912 |
| Adiponectin×Sex | 0.223 | 0.104 | 0.115 | 0.410 |
| Adiponectin | 0.125 | 0.066 | 0.092 | 0.274 |
| APOE4 | -0.060 | 0.575 | -0.045 | 0.727 |
| Adiponectin×APOE4 | 0.213 | 0.065 | 0.144 | 0.308 |
| Adiponectin | -0.062 | 0.717 | 0.076 | 0.670 |
| Education | -0.037 | 0.779 | 0.160 | 0.246 |
| Adiponectin×Education | 0.333 | 0.092 | 0.074 | 0.717 |
| Adiponectin | 0.213 | 0.014 | 0.102 | 0.328 |
| GDS | 0.058 | 0.624 | 0.013 | 0.927 |
| Adiponectin×GDS | -0.059 | 0.658 | 0.073 | 0.659 |
| Adiponectin | 0.226 | 0.011 | 0.081 | 0.456 |
| VRS | 0.013 | 0.911 | -0.061 | 0.673 |
| Adiponectin×VRS | -0.100 | 0.422 | 0.124 | 0.418 |
| Adiponectin | 0.492 | 0.085 | 0.732 | 0.029 |
| BMI | 0.146 | 0.229 | 0.198 | 0.174 |
| Adiponectin×BMI | -0.252 | 0.370 | -0.578 | 0.079 |
| Adiponectin | 0.199 | 0.207 | 0.061 | 0.749 |
| Annual income | 0.071 | 0.543 | 0.012 | 0.931 |
| Adiponectin×Annual income | -0.020 | 0.914 | 0.096 | 0.667 |
| Adiponectin | 0.331 | 0.118 | 0.133 | 0.617 |
| Lifetime physical activity | 0.044 | 0.718 | 0.002 | 0.989 |
| Adiponectin×Lifetime physical activity | -0.147 | 0.538 | -0.001 | 0.997 |
| Adiponectin | -0.324 | 0.796 | -1.389 | 0.368 |
| Albumin | -0.043 | 0.731 | -0.112 | 0.473 |
| Adiponectin×Albumin | 0.506 | 0.683 | 1.514 | 0.321 |
| Adiponectin | 0.618 | 0.065 | 0.132 | 0.777 |
| Fasting glucose | 0.136 | 0.230 | 0.016 | 0.917 |
| Adiponectin×Fasting glucose | -0.423 | 0.192 | 0.010 | 0.982 |
| Adiponectin | -0.056 | 0.814 | -0.096 | 0.730 |
| HDL-cholesterol | -0.172 | 0.129 | -0.200 | 0.137 |
| Adiponectin×HDL-cholesterol | 0.350 | 0.228 | 0.360 | 0.292 |
| Adiponectin | 0.129 | 0.579 | 0.249 | 0.460 |
| LDL-cholesterol | -0.018 | 0.877 | 0.016 | 0.913 |
| Adiponectin×LDL-cholesterol | 0.064 | 0.800 | -0.123 | 0.735 |
| Adiponectin | 0.489 | 0.105 | -0.096 | 0.793 |
| HOMA-IR | -0.228 | 0.432 | -0.012 | 0.948 |
| Adiponectin×HOMA-IR | -0.228 | 0.432 | 0.302 | 0.391 |
| Adiponectin | 0.514 | 0.307 | -0.492 | 0.430 |
| Zinc | 0.030 | 0.818 | -0.107 | 0.524 |
| Adiponectin×Zinc | -0.312 | 0.533 | 0.668 | 0.283 |
| Adiponectin | 0.147 | 0.054 | 0.161 | 0.084 |
| Alcohol | -0.210 | 0.084 | -0.054 | 0.714 |
| Adiponectin×Alcohol | 0.108 | 0.370 | -0.057 | 0.700 |
| Adiponectin | 0.170 | 0.012 | 0.090 | 0.275 |
| Smoking | -0.174 | 0.156 | -0.156 | 0.319 |
| Adiponectin×Smoking | 0.039 | 0.731 | 0.164 | 0.258 |
APOE4=apolipoprotein ε4, GDS=geriatric depression scale, BMI=body mass index, Aβ=beta-amyloid, =standardized beta coefficients. The moderation effects of potential covariate on the relationships between adiponectin and Aβ retention were examined by multiple linear regression analyses including two-way interaction term between adiponectin and any one of the confounders, as well as adiponectin itself, as an independent variable.
p < 0.05,
p < 0.01,
p < 0.001.