Figure 3.
Treatment with siponimod improved long-term neurologic deficits after ICH. (A) The corner turn test (CTT) was not significantly different between the siponimod-treated and vehicle-treated groups (F = 0.659, p = 0.628; p > 0.05 at each time point). Repeated measures ANOVA followed by Bonferroni’s post hoc test for the analysis of CTT. n = 12 mice per group. (B) Compared to the vehicle-treated group, siponimod treatment improved neurologic function evaluated with neurological deficit scores (NDS) in mice on days 3, 7, 14, and 28 (Wald χ2 = 15.597, p < 0.001). Generalized estimation equations (GEEs) for the analysis of the NDS. n = 12 mice per group. (C) Neurological deficit scores for individual tests on days 1, 3, 7, 14, and 28 (generalized estimation equations, n = 12 mice per group). The CTT data are expressed as mean ± SD, and the NDS data are presented as median and IQR.