Table 3.
Association of age at Onset of AD in patients with PRS.
| SAMPLE | MODEL | Effect size on age at onset (in years) | p‐value (of the PRS) | Mean age at onset in highest quintile PRS | Mean age at onset in lowest quintile PRS |
|---|---|---|---|---|---|
| All NIALOAD cases | AAO ~ APOE4num + PCs | −3.44 | <2e‐16 | ||
| All EFIGA cases | −2.92 | 7.70E‐15 | |||
| All NIALOAD cases | AAO ~ PRS + PCs | −0.61 | 0.0017 | 74.12 | 75.5 |
| NIALOAD cases with at least one APOE ε4 allele | −0.3 | 0.17 | 73.09 | 73.53 | |
| NIALOAD cases with no APOE ε4 allele | −1.36 | 0.00024 | 76.44 | 80.5 | |
| All EFIGA cases | −1.15 | 6.10E‐08 | 74.5 | 77.91 | |
| EFIGA cases with at least one APOE ε4 allele | −0.94 | 0.0018 | 73.31 | 75.8 | |
| EFIGA cases with no APOE ε4 allele | −1.1 | 0.00018 | 75.75 | 79.34 |