Table 4.

Penetrance of PRS and APOE‐ε4 allele in the NIA‐LOAD and EFIGA cohorts.

	Penetrance
	In everyone		In sibships
	APOE alone	PRS 1	APOE alone	PRS 1
NIALOAD
APOE ε4 allele	0.62		0.71
Non‐APOE ε4 allele (APOE ε3 or ε2 allele)	0.3		0.47
PRS in highest quintile		0.62		0.74
PRS in lowest quintile		0.3		0.48
APOE ε4 carriers and PRS in the highest quintile		0.74		0.81
APOE ε4 carriers and PRS in the lowest quintile		0.48		0.57
APOE ε4 non‐carriers and PRS in the highest quintile		0.44		0.62
APOE ε4 non‐carriers and PRS in the lowest quintile		0.16		0.31
PRS in highest decile		0.64		0.77
PRS in lowest decile		0.27		0.46
APOE ε4 carriers and PRS in the highest decile		0.77		0.84
APOE ε4 carriers and PRS in the lowest decile		0.43		0.57
APOE ε4 non‐carriers and PRS in the highest decile		0.47		0.64
APOE ε4 non‐carriers and PRS in the lowest decile		0.15		0.28
EFIGA
APOE e4 carriers	0.6		0.63
APOE e4 non‐carriers	0.44		0.48
Highest quintile		0.6		0.63
Lowest quintile		0.48		0.53
APOE e4 carriers and highest quintile		0.703		0.67
APOE e4 carriers and lowest quintile		0.53		0.52
APOE e4 non‐carriers and highest quintile		0.53		0.58
APOE e4 non‐carriers and lowest quintile		0.45		0.54

¹ Excludes single nucleotide polymorphisms in the 2 MB region surrounding APOE.