Table 5.
Penetrance of PRS in discordant sibling pairs in the NIA‐LOAD cohort.
| Proportion of discordant sibships with the higher PRS sibling being affected 1 | ||
|---|---|---|
| One sibling pair per family | Maximal sibling pairs per family | |
| Overall | 0.61 (0.02) | 0.60 (0.01) |
| PRS in highest quintile | 0.82 (0.03) | 0.82 (0.02) |
| PRS in Lowest quintile | 0.31 (0.06) | 0.31 (0.05) |
| APOE ε4 carriers and highest quintile | 0.85 (0.04) | 0.86 (0.03) |
| APOE ε4 carriers and lowest quintile | 0.35 (0.10) | 0.35 (0.07) |
| APOE ε4 non‐carriers and highest quintile | 0.72 (0.06) | 0.72 (0.05) |
| APOE ε4 non‐carriers and lowest quintile | 0.14 (0.13) | 0.14 (0.10) |
| PRS in highest decile | 0.88 (0.05) | 0.88 (0.04) |
| PRS in lowest decile | 0.26 (0.07) | 0.24 (0.05) |
| APOE ε4 carriers and highest decile | 0.85 (0.06) | 0.88 (0.05) |
| APOE ε4 carriers and lowest decile | 0.32 (0.11) | 0.31 (0.08) |
| APOE ε4 non‐carriers and highest decile | 0.89 (0.10) | 0.88 (0.09) |
| APOE ε4 non‐carriers and lowest decile | 0.09 (0.13) | 0.11 (0.97) |
1
From each family, one discordant sibship was randomly chosen to create a dataset. Proportion of discordant sibships where the sibling with the higher PRS was affected was computed. This process was repeated 100 times and the mean (standard deviation) of the proportion is reported.