Table 6.
Recurrence risk in NIA‐LOAD: Recurrence risk of a sibling with an affected proband carrying a high PRS (at different percentile levels of the distribution).
| Age‐range | Age specific prevalence of Alzheimer's disease (%) | Variable | Recurrence risk at PRS percentile level | |||
|---|---|---|---|---|---|---|
| 99th percentile | 95th percentile | 90th percentile | 80th percentile | |||
| 65–74 years | 3 | PRS 1 | 0.06 | 0.05 | 0.05 | 0.04 |
| PRS.AD 2 | 0.08 | 0.06 | 0.06 | 0.05 | ||
| 75–84 years | 17 | PRS | 0.27 | 0.24 | 0.23 | 0.22 |
| PRS.AD | 0.31 | 0.27 | 0.26 | 0.24 | ||
| 85 and above years | 32 | PRS | 0.45 | 0.42 | 0.40 | 0.39 |
| PRS.AD | 0.50 | 0.46 | 0.43 | 0.41 | ||
1
PRS was computed genome‐wide but excluding variants in the 2 MB window around the APOE gene (human genome b38, chromosome 19: 42,905,791–46,909,393).
2
PRS.AD represents the polygenic risk score that includes the effect of APOE ε4 and ε2 alleles. PRS.AD constructed with genome‐wide SNPs excluding the APOE region, but including the effect sizes SNPs that code for APOE‐ε4 (rs429358) and ‐ε2 (rs7412) alleles.