Table 7.
Recurrence risk in NIA‐LOAD: Empirical recurrence risk in siblings when probands are affected and carry a risk genotype (APOE or PRS in the highest quintile).
| Empirical recurrence risk 1 | ||||
|---|---|---|---|---|
| maximum sib‐pairs per family | One sib pair per family | |||
| APOE | PRS | APOE | PRS | |
| Proportion of younger sibling affected when older sibling is affected and is a APOE ε4 carrier | 0.78 (0.03) | 0.80 (0.03) | ||
| Proportion of younger sibling affected when older sibling is affected and is a APOE ε4 non‐carrier) | 0.75 (0.02) | 0.79 (0.03) | ||
| Proportion of younger sibling affected when older sibling is affected and has PRS in the highest quintile | 0.77 (0.04) | 0.78 (0.05) | ||
From each family, one sibship was randomly chosen to create a dataset. Empirical recurrence risk was computed as the proportion of sib‐pairs where the younger sibling was affected when the older sibling affected and carried a APOE ε4 allele (or had a highest quintile PRS). This process was repeated 100 times and the mean (standard deviation) of the proportion is reported. Similarly, for each family, maximum sib‐pair dataset was formed using each sibling only once (for example, 3 siblings can contribute one pair, 4 will contribute two pairs and so on). The empirical recurrence risk was re‐computed and the mean (standard deviation) across 100 iterations are reported.