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. 2023 May 2;10:1155835. doi: 10.3389/fcvm.2023.1155835

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© 2023 Cooke and Lai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Angiogenic transdifferentiation contributes to the expansion of the microvasculature, particularly in the setting of ischemia. Under the influence of inflammatory signaling (which increases DNA accessibility) and environmental cues (such as angiogenic cytokines, which provide transcriptional direction) some subset(s) of fibroblasts can transdifferentiate into endothelial cells. These induced endothelial cells contribute to the expansion of the microvasculature as a response to ischemia and augment tissue perfusion.