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. 2023 May 2;11:1182404. doi: 10.3389/fchem.2023.1182404

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Copyright © 2023 Lim, Yagnik, Henkel, Frost, Bien and Rothschild.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Multimodal imaging of an FFPE breast cancer tissue using dual-labeled Miralys™ probes. (A) Comparison of fluorescence (left) and MALDI-IHC (right) images for the dual-labeled vimentin and alpha smooth muscle actin (αSMA) probes. (B) Magnified region shown from the area within the yellow cross-hatched rectangles in A, for both fluorescence and MALDI-IHC images (left and right, respectively) of the αSMA probe. The center image is a bi-modal interactive merge of both the fluorescence and MALDI-IHC.